3,4,5-Trifluorophenylboronic acid, CAS 143418-49-9, is an organoboron compound used as an aryl building block in synthetic chemistry. Its boronic acid group can participate in palladium-catalyzed Suzuki–Miyaura cross-coupling, allowing the trifluorinated phenyl group to be incorporated into more complex molecules. Its molecular formula is C6H4BF3O2, and its molecular weight is approximately 175.90 g/mol. For procurement, buyers should confirm the required assay, impurity profile, packaging, and handling information against the supplier’s current product documentation.
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This compound consists of a phenyl ring bearing three fluorine atoms and a boronic acid group. In the name, “3,4,5-trifluoro” describes the positions of the fluorine substituents relative to the boronic acid-bearing carbon on the ring. The boronic acid functionality is the reactive handle commonly used to connect this aryl group to another molecular fragment. Its chemical identity is represented by CAS number 143418-49-9.
The formula, C6H4BF3O2, and molecular weight, approximately 175.90 g/mol, are useful for checking calculations and comparing supplier documents. As a practical conversion, 1.00 mmol of pure material corresponds to approximately 175.90 mg; the weighed amount may need adjustment for the stated assay. This conversion is a calculation from the molecular weight, not a claim about the assay or purity of any specific lot.
A primary use of 3,4,5-trifluorophenylboronic acid is as an organoboron coupling reagent. Under suitable reaction conditions, it can couple with an appropriate organic halide or related electrophile in the presence of a palladium catalyst and a base. The reaction can form a new carbon–carbon bond and introduce the 3,4,5-trifluorophenyl group into the target structure. The exact catalyst, solvent, base, temperature, and reaction time depend on the substrate and should be developed for the specific synthesis.
Fluorinated aromatic groups are used in research and development programs across medicinal chemistry, agrochemical chemistry, and materials-related synthesis. The presence of fluorine can change a molecule’s electronic properties and may influence its behavior, but the effect depends on the full molecular structure. This boronic acid supplies a defined substituted aryl fragment for synthesis; it does not by itself establish the performance, safety, or commercial suitability of the final molecule. Buyers should therefore evaluate it as a building block rather than as a finished functional ingredient.
These are potential research and synthesis uses, not guarantees that the compound will perform in every route. Organoboron reagents can show different reactivity depending on the coupling partner, reaction conditions, and material quality. A small-scale compatibility check is prudent before committing material to a larger campaign. For scale-up, assess both reaction performance and the handling and waste requirements of the complete process.
The core identity is the same regardless of supplier: 3,4,5-trifluorophenylboronic acid, CAS 143418-49-9. Commercial offers may differ in assay, impurity limits, pack size, and available documentation. Do not assume that a particular grade, packaging format, or solution form is available unless it is stated in the current quotation or product documents. If your process requires a specific grade or physical form, include it in the initial inquiry.
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For routine synthesis, buyers often begin by defining the required assay and the impurities that matter to their reaction or downstream purification. For regulated or tightly controlled projects, confirm whether the supplier can provide the documentation and quality controls required by your organization. A supplier’s standard specification may not automatically match a project-specific specification. Request written confirmation before placing an order.
| Specification | Why It Matters | What to Confirm |
|---|---|---|
| Identity | Confirms that the offered material matches the intended compound. | Name, CAS number 143418-49-9, and suitable identification data on product documents. |
| Assay or purity | Supports reaction calculations and helps assess suitability for the intended synthesis. | Acceptance limit, analytical method where available, and lot-specific result. |
| Impurity profile | Some impurities may affect reaction performance or downstream processing. | Relevant impurity limits or additional testing requirements for your process. |
| Appearance and physical form | Helps with receipt inspection and handling expectations. | Current description and whether the supplied form meets your operational needs. |
| Packaging and storage | Influence receiving, storage, and material handling procedures. | Pack size, container details, transport conditions, and storage guidance in the SDS or supplier documents. |
Do not rely on a generic online listing as a substitute for lot-specific documentation. The certificate of analysis should correspond to the supplied batch, while the safety data sheet should guide hazard communication and handling. If water content, residual solvents, or a particular trace impurity is critical, ask whether it is tested and whether a limit can be specified. Requirements that are not part of the standard specification should be agreed before order confirmation.
Start by identifying how the material will be used: exploratory screening, route development, or a defined production process. Set an assay requirement based on the chemistry and process controls rather than selecting a number without context. If the reaction is sensitive to impurities, share the relevant limits with the supplier so feasibility can be checked. Where practical, evaluate an initial quantity before committing to a larger requirement.
Confirm the product name, CAS number, pack size, batch documentation, and dispatch expectations in writing. Ask whether the quoted material is available from stock or subject to a production or sourcing lead time, since availability can vary. For repeat orders, discuss how specification consistency and change notification are handled. These checks help align purchasing, quality, and laboratory teams before the material is needed.
Maison Chemical supplies and exports chemicals for B2B customers, including buyers seeking 3,4,5-trifluorophenylboronic acid CAS 143418-49-9. We can review your target specification, required quantity, destination, packaging preference, and documentation needs to prepare a relevant quotation. Availability, lead time, and available quality documents should be confirmed for the specific order. We do not recommend assuming that custom limits or documents are included unless they are confirmed in writing.
To help us respond efficiently, include your intended application, required assay or impurity limits, target quantity, delivery location, and any documentation requirements in your inquiry. If you are evaluating a new route, tell us whether you need a small evaluation quantity or a larger planned supply. Our team can then clarify the options that can be offered for your request. Final suitability should be assessed by your technical and quality teams using the supplied documentation and your own process requirements.
3,4,5-Trifluorophenylboronic acid is a fluorinated arylboronic acid used chiefly as a building block in carbon–carbon bond formation, especially Suzuki–Miyaura coupling. Its key identity data are CAS 143418-49-9, formula C6H4BF3O2, and molecular weight approximately 175.90 g/mol. The right purchase specification depends on the intended reaction and the buyer’s quality requirements, so verify assay, impurities, packaging, and lot documentation before ordering. Contact Maison Chemical with your specification and quantity to request current availability, documentation, and a B2B quotation.
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